Small-molecule inhibitors and modulators of immune checkpoint receptors 2020-07-17T09:39:37+00:00

Small-molecule inhibitors and modulators of immune checkpoint receptors

Modulation or/and inhibition of the immune checkpoints receptors have become the subject of growing interest for new therapies in immuno-oncology. Immune check point receptors expressed by immune cells can have either inhibitory or stimulatory functions.

Two strategies for immunotherapy have been investigated:

  • Inhibition of immune checkpoint blockade (ICB) to restore T cell activity,
  • Activation of stimulatory checkpoints to stimulate T cell activity.

Assessing the effect of drug candidates, such as small molecules or biologics, on the immune checkpoint interactions is now a major challenge for research and drug discovery.

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