Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3
KIR3DL3
Alternative names CD158z
Known ligands HHLA2
Origin Homo sapiens
Accession number Q8N743
Catalog number Protein construct Tag Expression host Biologically active Application
R1-040-1 KIR3DL3 ECD (26-322) Fc-tag CHO TBD TBD
R1-040-1a KIR3DL3 ECD (26-322) Tag free CHO Yes ELISA, WB, functional studies
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KIR3DL3 also known as CD158 antigen-like family member Z (CD158z) or killer cell inhibitory receptor 1 exists as: transmembrane glycoprotein, include 3 of extracellular immunoglobin (Ig) domains (3D) and a long (L) cytoplasmic domain. The cytoplasmic tail contain one immunoreceptor tyrosine-based inhibitory motif  (ITIM) (1). Human KIR3DL3 cDNA encodes a 410 amino acid (aa) polypeptide precursor with a 25 aa signal peptide, a 297 aa extracellular domain (ECD) with 3 Ig-like domains (3D), a 21 aa transmembrane domain, and a 67 aa cytoplasmic domain (long). Within ECD human KIR3DL3 shares 47% and 44% aa sequence identity with mouse and rat KIR3DL3, respectively(2). The KIR3DL3 gene also differs from the other KIRs in that it lacks the exon encoding the linker region between the Ig domains and the transmembrane region (2). KIR3DL3 is expressed by natural killer (NK) cells and T-cell subsets (1). Protein expression might be induced under certain developmental or pathological situations (1). KIR3DL3 is as an inhibitory receptor for HHLA2 (3).

  1. Trundley A. E. et. al. Molecular characterization of KIR3DL3. Immunogenetics 2006 Jan: 57: 904–916.
  2. Hollenbach J. A. et. al. Killer cell immunoglobulin-like receptor (KIR) gene content variation in the HGDP-CEPH populations. Immunogenetics 2012 Oct;64(10):719-37
  3. Bhatt R. S. et al. KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1. Cancer Immunol Res. 2021 Feb; 9(2): 156–169.