CD70 antigen
CD70
Alternative names TNFSF7
Known ligands CD27
Origin Homo sapiens
Accession number P32970
Catalog number Protein construct Tag Expression host Biologically active Application
R1-023-1 CD70 ECD (39-193) His-tag, Fc-tag CHO Yes ELISA, WB, functional studies
R1-023-1a CD70 ECD (39-193) His-tag CHO Yes ELISA, WB, functional studies
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CD70 is a type II transmembrane protein with an apparent molecular mass of 50 kD. CD70 is a member of the tumor necrosis factor superfamily (TNFSF7) and is also designated CD27 ligands (1). The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation (2).  Diseases associated with CD70 include Lymphoproliferative Syndrome 3 and Acute Myocarditis. Among its related pathways are PEDF Induced Signaling and TRAF Pathway.

  1. Hintzen RQ, Lens SM, Beckmann MP, Goodwin RG, Lynch D, van Lier RA. Characterization of the human CD27 ligand, a novel member of the TNF gene family. J Immunol. 1994 Feb 15;152(4):1762-73. PMID: 8120385.
  2. Starzer AM, Berghoff AS. New emerging targets in cancer immunotherapy: CD27 (TNFRSF7). ESMO Open. 2020 Mar;4(Suppl 3):e000629. doi: 10.1136/esmoopen-2019-000629. PMID: 32152062; PMCID: PMC7082637.