Alternative names | TNFSF7 |
Known ligands | CD27 |
Origin | Homo sapiens |
Accession number | P32970 |
CD70 is a type II transmembrane protein with an apparent molecular mass of 50 kD. CD70 is a member of the tumor necrosis factor superfamily (TNFSF7) and is also designated CD27 ligands (1). The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation (2). Diseases associated with CD70 include Lymphoproliferative Syndrome 3 and Acute Myocarditis. Among its related pathways are PEDF Induced Signaling and TRAF Pathway.
- Hintzen RQ, Lens SM, Beckmann MP, Goodwin RG, Lynch D, van Lier RA. Characterization of the human CD27 ligand, a novel member of the TNF gene family. J Immunol. 1994 Feb 15;152(4):1762-73. PMID: 8120385.
- Starzer AM, Berghoff AS. New emerging targets in cancer immunotherapy: CD27 (TNFRSF7). ESMO Open. 2020 Mar;4(Suppl 3):e000629. doi: 10.1136/esmoopen-2019-000629. PMID: 32152062; PMCID: PMC7082637.