PD-1 2020-07-17T09:37:37+00:00

Programmed cell death protein 1 (PD-1)

Programmed cell death protein 1 (PD-1; CD279; PDCD1) is a 288 amino acid (aa) type I transmembrane protein expressed on T cells, B cells, natural killer T cells, activated monocytes, and dendritic cells (1). PD-1 belongs to the CD28 family of receptors and contains two tyrosine-based signaling motifs: a tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) (2) (1). PD-1 has two known ligands, PD-L1 (B7-H1; CD274) and PD-L2 (B7-DC; CD273), members of B7 family (1) (2). Engagement of PD-1 by its ligands leads to the inhibition of T cell receptor-mediated lymphocyte proliferation and cytokine secretion which leads to exhaustion and apoptosis of tumor-specific T cells (3). Therefore PD-1 plays critical roles in the regulation of autoimmunity, tumor immunity, infectious immunity, transplantation immunity, allergy and immune privilege (4).

  1. Riella LV et al. Role of the PD-1 Pathway in the Immune Response. American Journal of Transplantation. 2012, 12, pp. 2575–2587.
  2. Chen L and Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Reviews Immunology. 2013, Vol. 13, 4, pp. 227-242.
  3. Freeman GJ et al. Engagement of the PD-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation. Journal of Experimental Medicine. 2000, Vol. 192, 7, pp. 1027-1034.
  4. Okazaki T and Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. International Immunology. 2007, Vol. 19, 7, pp. 813–824

Sequence (Q15116)

MQIP – secretion signal sequence

CSRAAR – intracellular domain

PGWFL – ectodomain

C — C – disulfide bond

VGVVG – transmembrane domain

N – glycosylation site

Cat number Protein construct Tag Expression Host Order
R1-001-1 PD-1 ECD (25-167) Fc-tag CHO K1 Order
R1-001-1a PD-1 ECD (25-167) Tag free CHO K1 Order
R1-001-2 PD-1 ECD (25-167) His-tag, Fc-tag CHO K1 Order
R1-001-2a PD-1 ECD (25-167) His-tag CHO K1 Order
R1-001-3 PD-1 ECD (34-150) Tag free E. coli Order
R1-001-3.1 (15N) PD-1 ECD (34-150) Tag free E. coli Order
new sex video bbwxxx free porn hindi sex sex video rujizz xxx hd porn hd sex beeg porn Vidéos porno Arab Porn BigoBang Porner Vip Porn Xxx Club Let jerk Me Hd Porn Videos Lowap Porn FireWap Piggy Tube Watch My Porn Beeg Porn Fuq Tube Bigo Bang Big Wap Porn Porn Videos X Via Porn Videos hindi sex