Immune checkpoint inhibitors and modulators

/Immune checkpoint inhibitors and modulators
Immune checkpoint inhibitors and modulators 2019-02-26T13:34:05+00:00

Modulation or/and inhibition of immune checkpoints receptors have become the subject of growing interest for new therapies in immuno-oncology. Immune check point receptors expressed by immune cells can have either inhibitory or stimulatory functions.

Two strategies for immunotherapy have been investigated:

  • Inhibition of checkpoint blockade to restore T cell activity,
  • Activation of stimulatory checkpoints to stimulate T cell activity.

Assessing the effect of a drug candidates such as small molecules or biologics on the immune checkpoint interactions is now a major challenge for research and drug discovery.