NMR 2020-06-26T11:13:43+00:00

AIDA-NMR 2D 1H-15N HSQCs (a-f)

Figure 1: a) human PD-1 (hPD-1); b) complex of hPD-1/hPD-L1; c) complex of hPD-1/hPD-L1 with Compound 1; d) complex of hPD-1/hPD-L1 with Compound 2. Compounds 1 and 2 are too weak inhibitors and do not dissociate the hPD-1/hPD-L1 complex; e) positive control of complex of hPD-1/hPD-L1  + Compound 1 + Reference compound. After addition of the Reference compound, a well-known PD-L1 inhibitor, the complex dissociates; f) complex of hPD-1/hPD-L1 + Compound 3; Compound 3 is a potent PD-L1 inhibitor and it dissociate the hPD-1/hPD-L1 complex and the spectrum of the PD-1 protein is recovered.

bbwxxx free porn hindi sex sex video rujizz xxx hd porn hd sexdash porn videohd warning porn beeg porn redwap xxx videos babe porn new sex video hindi sex wp theme xxx xxxporn free porn hd sesso video porn videos videos de sexo freierporno free porn hindi xxx